The Royal Australian and New Zealand College of Radiologists (RANZCR) has reinforced Australia and New Zealand at the forefront of the application of artificial intelligence (AI) in healthcare with the release of world-leading AI Standards of Practice. The Standards provide a risk-management framework to ensure the safe application of AI in radiology practice. AI can help clinicians to better diagnose illness, coordinate treatment plans and increase the efficiency of care delivery across healthcare. Overall, they will allow for a more efficient and accessible healthcare system that delivers improved outcomes for patients.